Description

Molecular Details of Retatrutide

• Molecular Formula:
  C187H291N51O59

• Molecular Weight (Monoisotopic):
  4187.65 g/mol

• Peptide Type:
  Synthetic triple agonist
  Activates GLP-1, GIP, and glucagon receptors

• Structure:
  Modified 39-amino acid linear peptide, stabilized with C-terminal amidation and fatty acid conjugation to extend half-life

🧬 Mechanism of Action (Research Use Only):

• GLP-1 receptor agonism: Enhances insulin secretion, delays gastric emptying, reduces appetite

• GIP receptor agonism: Amplifies glucose-dependent insulin release, may aid fat metabolism

• Glucagon receptor agonism: Increases energy expenditure and lipid mobilization

• Combined triple agonist effect → significant improvements in weight reduction, glucose regulation, and energy balance in preclinical/clinical research

🧪 Research Applications:

• Obesity research (investigational compound for weight reduction)

• Type 2 diabetes models (glucose and insulin regulation)

• Metabolic health (fat oxidation, energy expenditure)

• Comparative studies against Semaglutide and Tirzepatide

📑 Storage & Handling (Research Use Only):

• Form: Lyophilized peptide powder

• Common Dosages (research vials): 2 mg or 5 mg

• Storage:

  • Lyophilized: Store at −20 °C

  • Reconstituted: Store at 2–8 °C (stable 7–14 days)

• Reconstitution: Sterile bacteriostatic water

• Solubility: Water-soluble

• Use: For laboratory research only. Not for human or veterinary use.