Description

Molecular Details

• Molecular Formula: C26H28ClNO

• Molecular Weight: ~ 405.96 g/mol

• Compound Type: Selective Estrogen Receptor Modulator (SERM)

• Isomer Relation: Active trans-isomer of Clomiphene citrate (the other isomer being Zuclomiphene).

Mechanism of Action (Research Use Only)

• Acts as an estrogen receptor antagonist in the hypothalamus.

• Blocks negative feedback from estrogen, leading to increased GnRH secretion.

• In turn, this stimulates LH and FSH release from the pituitary.

• Elevated LH/FSH increases testicular testosterone production in research models.

Research Applications

• Male hypogonadism research: Studied as an alternative to testosterone replacement.

• Fertility studies: Investigated for restoring hormonal balance while maintaining spermatogenesis.

• Endocrinology models: Useful in examining feedback loops of the hypothalamic-pituitary-gonadal (HPG) axis.

Storage & Handling (Research Use Only)

• Form: Typically supplied as a citrate salt in powder or capsule form.

• Storage: Store at room temperature (20–25 °C), dry and protected from light.

• Use: For laboratory research only. Not for human or veterinary use.