Description

Molecular Details

• Molecular Formula: C63H88CoN14O14P

• Molecular Weight: ~ 1355.37 g/mol

• Compound Type: Water-soluble vitamin (part of the B-complex)

• Core Structure: Contains a corrin ring with a central cobalt ion.

Mechanism of Action (Research Use Only)

Vitamin B12 serves as an essential cofactor in enzymatic reactions.

Key points:

• Involved in DNA synthesis and cellular energy metabolism.

• Cofactor for methionine synthase (homocysteine → methionine conversion).

• Cofactor for methylmalonyl-CoA mutase (fatty acid and amino acid metabolism).

• Supports red blood cell formation, neurological health, and myelin synthesis in research models.

Research Applications

• Hematology: Studied for its role in preventing megaloblastic anemia.

• Neurology: Explored for roles in cognitive function, neuroprotection, and peripheral nerve regeneration.

• Metabolism studies: Used to examine one-carbon metabolism and homocysteine regulation.

• Anti-aging research: Investigated for mitochondrial function and oxidative stress reduction.

Forms of Vitamin B12

• Cyanocobalamin – synthetic form, stable, widely used in supplements.

• Methylcobalamin – active coenzyme form, involved in methylation pathways.

• Adenosylcobalamin – mitochondrial active form.

• Hydroxocobalamin – naturally occurring form, long half-life, sometimes studied for detox effects.

Storage & Handling (Research Use Only)

• Form: Often supplied as lyophilized powder or injectable solution.

• Storage: 2–8 °C for solutions; −20 °C for long-term dry storage.

• Solubility: Water-soluble.

• Use: For laboratory research only. Not for human or veterinary use.