Description

Molecular Details

• Molecular Formula: C187H300N52O59S

• Molecular Weight: ~ 4080 g/mol

• Peptide Type: Long-acting amylin analogue

• Origin: Synthetic derivative of human amylin with amino acid substitutions to increase stability and half-life.

Mechanism of Action (Research Use Only)

Cagrilintide acts as an amylin receptor agonist. Amylin is a peptide hormone co-secreted with insulin from pancreatic β-cells.

Key points:

• Activates amylin and calcitonin receptors, regulating satiety and food intake.

• Slows gastric emptying, leading to prolonged nutrient absorption.

• Reduces body weight and food consumption in metabolic research models.

• Long half-life (~5–8 days in studies), allowing weekly administration.

Research Applications

• Obesity and weight management studies: Investigated for appetite suppression and sustained weight loss.

• Diabetes research: Studied in combination with GLP-1 receptor agonists (like Semaglutide) for synergistic effects.

• Energy balance and metabolism models: Explored in regulating satiety signals and nutrient utilization.

Storage & Handling (Research Use Only)

• Form: Lyophilized peptide powder.

• Storage:

  • Lyophilized: −20 °C long term.

  • Reconstituted: 2–8 °C (stable ~7–10 days).

• Reconstitution: Sterile bacteriostatic water.

• Solubility: Fully water-soluble.

• Use: For laboratory research only. Not for human or veterinary use.