Description

Molecular Details of Semaglutide

• Molecular Formula:
  C187H291N45O59

• Molecular Weight (Monoisotopic):
  4113.58 g/mol

• Peptide Type:
  Synthetic GLP-1 receptor agonist
  Modified analog of human glucagon-like peptide-1 (GLP-1)

• Structure Modifications:

  • Substitution of alanine with Aib (α-aminoisobutyric acid) at position 8 (resists DPP-4 degradation)

  • Lysine at position 26 conjugated with a C18 fatty diacid chain via a glutamate spacer (prolongs half-life)

  • Half-life ≈ 7 days → allows once-weekly dosing in clinical research

🧬 Mechanism of Action (Research Use Only):

• Selective GLP-1 receptor agonist

• Enhances glucose-dependent insulin secretion

• Delays gastric emptying, reducing postprandial glucose spikes

• Acts on hypothalamic satiety centers to reduce appetite and food intake

• Improves glycemic control and promotes weight reduction in obesity and diabetes models

🧪 Research Applications:

• Obesity and weight management models

• Type 2 diabetes research (insulin sensitivity, beta-cell preservation)

• Cardiometabolic health (lipids, blood pressure, inflammation)

• Comparative studies vs. Tirzepatide and Retatrutide for metabolic outcomes

📑 Storage & Handling (Research Use Only):

• Form: Lyophilized peptide powder

• Common Dosages (research vials): 2 mg or 5 mg

• Storage:

  • Lyophilized: Store at −20 °C

  • Reconstituted: Store at 2–8 °C (stable 7–14 days)

• Reconstitution: Sterile bacteriostatic water

• Solubility: Water-soluble

• Use: For laboratory research purposes only. Not for human or veterinary use.