Description

Molecular Details of IGF-1 LR3

• Molecular Formula:
  C400H625N111O115S9

• Molecular Weight (Monoisotopic):
  9111.00 g/mol

• Peptide Type:
  Synthetic IGF-1 analog
  Modified to increase stability, potency, and half-life

• Amino Acid Length:
  83 amino acids (vs. 70 in native IGF-1)

• Key Modifications:

  • Arginine substitution at position 3 (hence Long R3)

  • 13 additional amino acids added at the N-terminus

  • Reduces affinity for IGF-binding proteins (IGFBPs) → increases bioavailability and activity

🧬 Mechanism of Action (Research Use Only):

• Binds to IGF-1 receptor (IGF1R), activating the PI3K/AKT and MAPK pathways

• Promotes cell proliferation, survival, and protein synthesis

• Enhances muscle hypertrophy, neuroprotection, and tissue regeneration

• Longer half-life (~20–30 hours) compared to native IGF-1 (~12–15 minutes)

🧪 Research Applications:

• Muscle repair and regeneration models

• Neuroregenerative studies (nerve injury, neuroprotection)

• Tissue healing and wound repair

• Anti-aging and longevity studies

• Cachexia and muscle wasting research

• Often compared with or stacked with PEG-MGF or GH secretagogues

📑 Storage & Handling (Research Use Only):

• Form: Lyophilized peptide powder

• Common Dosages: 1 mg or 2 mg per vial

• Storage:

  • Lyophilized: Store at −20 °C

  • Reconstituted: Store at 2–8 °C (stable for 7–14 days)

• Reconstitution: Sterile bacteriostatic water

• Solubility: Water-soluble under physiological pH

• Use: For laboratory research purposes only. Not for human or veterinary use.